E1260
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E1260
Sigma
L -Ethionine
≥99% (TLC)
| Synonym: | |
| CAS Number: | 13073-35-3 |
| Linear Formula: | C2H5SCH2CH2CH(NH2)CO2H |
| Molecular Weight: | 163.24 |
| EC Number: | 235-966-4 |
| MDL number: | MFCD00002626 |
| PubChem Substance ID: | 24894397 |
Description
| Biochem/physiol Actions | An analog of methionine that interferes with the normal methylation of DNA and other methylation pathways, and induces pancreatic toxicity and liver cancer. However, in animal studies, it has also been shown to act synergistically with methionine-depletion to block the growth and metastasis of methionine-dependent tumors. |
Properties
| assay | ≥99% (TLC) |
| mp | 280 °C (dec.)(lit.) |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| WGK Germany | 3 |
| RTECS | ES6825300 |
References
| reference | Longnecker, D.S., Abnormal methyl metabolism in pancreatic toxicity and diabetes. J. Nutr. 132, 2373S-2376S, (2002) |
| Guo, H., et al., Methionine depletion modulates the antitumor and antimetastatic efficacy of ethionine. Anticancer Res. 16, 2719-2723, (1996) | |
| Poirier, L.A., The effects of diet, genetics and chemicals on toxicity and aberrant DNA methylation: an introduction. J. Nutr. 132, 2336S-2339S, (2002) | |
| Merck | Merck 13,3774 |
| Beilstein | Beil. 4,III,1643 |
| Corp MSDS 1, 1550:B / FT-IR 2 (1), 941:C / FT-IR 1 (1), 595:C / IR-Spectra (3), 354:D / NMR-Reference 2 (1), 502:A / RegBook 1 (1), 675:C / Sax 6, 218 / Sigma FT-IR 1 (1), 158:C / Structure Index 1, 101:B:9 |
